Bầu cử Thượng viện Hoa Kỳ tại Pennsylvania năm 2016

The 2016 United States Senate election in Pennsylvania took place on November 8, 2016, to elect a member of the United States Senate to represent the Commonwealth of Pennsylvania, concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in numerous other states, elections to the United States House of Representatives, and various state and local elections. The primaries were held on April 26.

Incumbent Republican U.S. Senator Pat Toomey was reelected to a second term in a close race, defeating Democratic nominee Katie McGinty and Libertarian Party nominee Edward Clifford. If McGinty had won, she would have become Pennsylvania's first female U.S. senator. With a margin of 1.43%, this election was the second-closest race of the 2016 Senate election cycle, behind only the election in New Hampshire.

As of 2025, Toomey was the last Republican U.S. senatorial candidate to win the counties of Bucks, Centre, Dauphin, and Erie; and the last Republican ever to win Chester County, which has trended Democratic in recent years.