The United States Senate election of 1948 in Massachusetts was held on November 2, 1948. Republican incumbent Leverett Saltonstall was re-elected to a second term in office over John I. Fitzgerald.
Republican primary
Candidates
- Leverett Saltonstall, incumbent U.S. senator since 1945
Results
Senator Saltonstall was unopposed for renomination.
Democratic primary
Candidates
- John I. Fitzgerald, former Boston fire commissioner and member of the Boston City Council
- Francis D. Harrigan, Boston attorney and candidate for governor in 1946
- Joseph A. Langone Jr., Boston election commissioner and former state senator
- John D. Lynch, member of the Cambridge City Council and former mayor of Cambridge
- Richard M. Russell, former U.S. representative and mayor of Cambridge
General election
Candidates
- Henning A. Blomen, perennial candidate (Socialist Labor)
- John I. Fitzgerald, former Boston fire commissioner and member of the Boston City Council (Democratic)
- Leverett Saltonstall, incumbent U.S. senator since 1945 (Republican)
- E. Tallmadge Root, nominee for Senate in 1944 and governor in 1940 (Prohibition)