The 1922 United States Senate election in Massachusetts was held on November 7, 1922. Republican incumbent Henry Cabot Lodge was narrowly re-elected to a sixth term in office over Democratic banker William A. Gaston.
Republican primary
Candidates
- Henry Cabot Lodge, incumbent Senator and Senate Majority Leader
- Joseph H. Walker, former Speaker of the Massachusetts House of Representatives
Campaign
Walker accused Lodge of having "reactionary" tendencies and not properly representing the Republican Party.
Democratic primary
Candidates
- William A. Gaston, nominee for governor in 1902 and 1903 and son of former Governor William Gaston
- Dallas Lore Sharp, author and Boston University professor
- John Jackson Walsh, former state senator and 1920 gubernatorial nominee
- Sherman L. Whipple, attorney and candidate for U.S. Senate in 1911 and 1913
General election
Candidates
- Washington Cook, rubber manufacturer and brother of Alonzo B. Cook (Independent)
- William A. Gaston, nominee for governor in 1902 and 1903 and son of former Governor William Gaston (Democratic)
- Henry Cabot Lodge, incumbent Senator since 1893 (Republican)
- John A. Nicholls (Prohibition Progressive)
- John Weaver Sherman (Socialist)
- William E. Weeks, former Mayor of Everett (Progressive)
Campaign
Washington Cook ran on a platform that supported the League of Nations, women's suffrage, enforcement of the 18th Amendment, measures to stop the lynching of African-Americans in the south, creation of a national divorce law, and adequate compensation for soldiers.