The 1982 United States Senate election in Maine took place on November 2, 1982. Edmund Muskie, elected in the 1976 Senate election, resigned his seat in 1980 to become Secretary of State. Incumbent Senator George J. Mitchell, who was appointed to the seat on May 17, 1980, by Governor Joseph E. Brennan, won election to a full six-year term, defeating Congressman David F. Emery by 99,937 votes. Mitchell carried 15 of Maine's 16 counties, with Emery only winning Knox County.
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