2022 United States Senate election in Pennsylvania

The 2022 United States Senate election in Pennsylvania was held on November 8, 2022, to elect a member of the United States Senate to represent the Commonwealth of Pennsylvania. Democratic Lieutenant Governor John Fetterman won his first term, defeating Republican surgeon Mehmet Oz. Fetterman succeeded Republican incumbent senator Pat Toomey, who did not seek re-election to a third term. This was the only U.S. Senate seat to flip parties in 2022, and one of the two Republican-held Senate seats up for election in a state that Joe Biden won in the 2020 presidential election.

In the May 17 primary, Fetterman won the Democratic nomination with 59% of the vote over Congressman Conor Lamb and state Representative Malcolm Kenyatta. Oz finished with a 0.1% margin ahead of businessman Dave McCormick in the Republican primary, triggering an automatic recount. McCormick conceded the nomination on June 3, making Oz the first Muslim candidate to be nominated by either major party for U.S. Senate.

The general election was among the most competitive of the 2022 midterms and characterized as highly contentious. Fetterman framed Oz as an elitist carpetbagger with a radical anti-abortion stance in the wake of Dobbs v. Jackson Women's Health Organization overturning Roe v. Wade, while Oz framed Fetterman as a socialist insufficiently committed to fighting crime. Fetterman's health was also a major issue due to him suffering a stroke days before his primary victory. Although Fetterman led most pre-election polls, concerns towards his health and a scrutinized debate performance helped Oz take a narrow lead before the election.

Despite Oz's lead in final polls, Fetterman won by a 4.9% margin, helping provide Senate Democrats a net gain of one seat and their first outright majority since 2015. With Fetterman's victory, elected Democrats held both U.S. Senate seats from Pennsylvania for the first time since 1947.